Risk factors associated with Diabetes Mellitus in COVID-19 infected patients: A meta-analytic synthesis of observational studies (preprint)

Aims: : We carried out a systematic literature review and meta-analytic synthesis to find out association between DM and related outcomes in patients with COVID-19 infection. Methods: We systematically searched MEDLINE, and Web of Science to identify studies investigating comorbidities, clinical manifestations and resource utilization of diabetic patients exposed with COVID-19 published from inception to January 2021. Meta-analysis was carried out using Review Manager 5.3. Random effects model was used to compute the pooled estimates of odds ratio/mean difference (OR)/(MD) and 95% confidence intervals (CI). Results: Results from the pooled meta-analysis found that CVD, hypertension, AKI, cerebrovascular disease, AKI and ARDS were significantly associated with DM in COVID-19 infected patients compared to non-diabetic patients. There is significant association found between mortality and DM compared to non-diabetic patients [OR (95% CI): 2.46 (1.68, 3.58)]. ICU admission and use of mechanical ventilation was significantly associated with DM and COVID-19 vs. non-diabetic [OR (95% CI): 2.79 (1.79,4.34) and 3.33 (2.05, 5.42)] respectively. However, LOS, hospitalization, and ICU admission were not significantly differing between diabetes vs. non-diabetes. Conclusions: The results showed a significant association between mortality and DM exposed with COVID-19. Other co-morbidities especially CVD/hypertension could be a serious threat for DM COVID-19 infected patients for the higher mortality.

Four-phase safety checklist for health care providers in COVID-19 hospitals: a practical tool for survival!

Pandemic of coronavirus disease 2019 (COVID-19) has generated immense viral exposure risk among frontline health care providers (HCPs), especially due to aerosol-generating events and procedures. This further increased the risk of serious mental health disorders amongst them. Hitherto, there is lack of any specific safety protocol specially during the pre- and post-exposure period for HCPs, who provide direct clinical care to patients suffering from COVID-19. We propose a four-phase checklist approach, which may help them in mental preparedness as well as organizing themselves prior and following virus exposure in clinical postings and may enhance the safety standards. The checklist comprises simple steps and may work as a documented track record of precautionary and preventive measures which must be followed by HCWs working in dedicated COVID-19 hospitals.